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Rubella causes a mild rash illness of children and adults known as German measles. There is often pharyngitis and enlargement of the cervical lymph nodes. Infection often occurs during childhood with many infections being asymptomatic and complications being rare. However, infection of women in the first 16 weeks of pregnancy can lead to congenital defects developing in the foetus such as cataracts, nerve deafness and cardiac abnormalities. Antibody in women of childbearing age protects the foetus from being infected and thereby prevents congenital abnormalities from developing. Rubella virus is classified as a toga virus. It is immunologically distinct from other known viruses. The virus particle is spherical with a diameter of 60 - 70 nm and contains a single strand of RNA in a nucleocapsid surrounded by a lipid envelope. It has three structural proteins; E1 and E2, which are associated with the viral envelope and C which forms the nucleocapsid with RNA. E1 is reactive with IgM and IgG antibodies and is the antigen responsible for haemagglutination activity. E2 and C induce IgG antibodies but E1 is most important to antibody testing.
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Inactivation & Safety — Each lot of Rubella antigen is inactivated using ultraviolet radtiation and this inactivation verified using a sensitive tissue culture based infectivity assay. Microbix’ proprietary inactivation strategy is the best in the industry, and provides the highest level of safety you will find.
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Each antigen lot is tested for potency using ELISA, and compared to a reference antigen. This ensures the amount of viral protein in each batch is consistent. The total protein concentration reported includes both viral and non-viral proteins, with the ratio dependent on the purity of the antigen. View our Quality Policy and ISO Certification.