Toxoplasma tachyzoites are extracted from optimally infected cell culture and centrifugation removes cellular protein and enriches the product for whole, intact toxoplasma and a high concentration of all toxoplasma membrane proteins.
Toxoplasma in healthy individuals is most often asymptomatic. When symptomatic disease occurs it often resembles mononucleosis or may be limited to an ocular infection. Subclinical infections may surface some years after infection when the individual becomes immunocompromised. In these patients the result is often cerebral infection. Congenital infections are the primary area of concern, as the symptoms may involve severe defects of the central nervous system and eyes which is often fatal.
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Inactivation & Safety — Each lot of Toxoplasma antigen inactivated using detergent treatment and this inactivation verified using a sensitive tissue culture based infectivity assay.
Applications — Many types of IgG and IgM immunoassays